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Furthermore, both SM and exenatide selectively activated p38 MAPK phosphorylation in the spinal cord, providing additional evidence that SM exerts its anti-allodynic effects by targeting spinal GLP-1R and promoting microglial -endorphin synthesis via the p38 MAPK signaling cascade [72]

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The weight-loss results continued to the 48-week endpoint, with the 12 mg retatrutide group achieving a mean weight reduction of -24.2%, while the placebo group only saw a -2.1% change

As scientific understanding of obesity, insulin signaling, and hormonal regulation continues to evolve, compounds like Retatrutide may contribute valuable insights into future therapeutic research pathways

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